![]() ![]() As well as binding T cell receptors on CD8 + T cells, HLA class I molecules are important ligands for inhibitory and activating killer immunoglobulin-like receptors (KIRs) which are found on natural killer cells and some T cells for the CD94:NKG2 family of receptors also expressed mainly by NK cells and for leukocyte immunoglobulin-like receptors (LILRs) on myeloid cells. However, given the diverse receptors which are bound by HLA class I molecules, alternative interpretations are possible. ![]() HLA class I associations are often interpreted in the light of ‘protective’ or ‘detrimental’ CD8 + T cell responses which are restricted by the host HLA class I allotype. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. ![]()
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